科研团队

首页  科学研究  科研团队

组织器官发育和相关疾病的遗传调控团队

日期:2022-09-30   点击数:5351  


科研团队:组织器官发育和相关疾病的遗传调控

团队网站:/ldsys/main.htm

  1. 团队简介:

亚博赞助阿根廷球队“组织器官发育和相关疾病的遗传调控”团队的主要研究方向为:1、生理和病理条件下血管新生的遗传调控;2、神经发育以及相关疾病的发病机制;3、基于血管内皮细胞、毛细胞和运动神经元行为的化合物筛选。团队在模式生物斑马鱼和小鼠模型上,利用多种遗传操作技术、活体成像、高通量测序等手段探索相关疾病的发病机制和干预的理论依据。

二、团队负责人简介:

刘东 博士, 教授, 博士生导师。江苏省杰出青年基金获得者、江苏省第五期“333高层次人才培养工程”培养对象、江苏省“六大人才高峰”高层次人才培养对象、获江苏省“双创计划”资助。他是美国心脏协会American Heart Association会员,中国解剖学会再生医学专业委员会委员,中国生物物理学会听觉分会委员,青年委员会常务委员。近三年来发表SCI论文30篇,累计影响因子超过130,其中以通讯作者发表SCI 论文20篇,其中包括知名杂志CardiovascularResearch、Cell Research和Oncogene等。近5年来以项目主持人身份获得共10项国家级、省部级科研以及人才项目资助。

三、团队成员:

石运伟 博士、助理研究员(神经再生重点实验室)

王新 实验师(神经再生重点实验室)

巩杰 博士,副教授,硕士生导师

段叙初 博士、讲师

魏官云 博士、讲师

蔡成芸 博士、讲师

王琤博士、讲师

卢晓凤 博士、讲师

郝文璟 博士、讲师

研究生:

钱付平

王晓宁

钱佩佩

赵金湘

徐梦婷

张旭

黄自刚

胡越波

客座研究人员:

秦银银(宿迁第一人民医院)

吕峰 博士(南通科技学院)

四、在研课题

2019-2022: 国家自然科学基金-面上项目:血管新生的遗传调控(刘东)

2016-2019: 国家自然科学基金-面上项目:血管新生的遗传调控(刘东)

2013-2015: 国家自然科学基金-青年项目:血管新生的遗传调控(刘东)

2018-2021: 江苏省自然科学基金-杰出青年基金项目:血管新生的遗传调控(刘东)

2012-2015: 江苏省自然科学基金-青年基金项目:血管新生的遗传调控(刘东)

2017-2020: 江苏省高校自然科学研究项目-重大项目:血管新生(刘东)

2016-2019: 江苏省“六大人才高峰”高层次人才培养对象:血管新生(刘东)

2014-2016: 江苏省“双创计划”博士计划,境外世界名校创新类计划(刘东)

2012-2014: 江苏省高校自然科学研究项目-面上项目:血管新生(刘东)

石运伟:国家自然科学基金-面上项目:

王新:国家自然科学基金-青年项目

巩杰:国家自然科学基金-青年项目

段旭初:国家自然科学基金-青年项目

魏官云:江苏省自然科学基金-青年基金项目

巩杰:江苏省自然科学基金-青年基金项目

段旭初:江苏省高校自然科学研究项目-面上项目

横向课题一:2018/08-2018/12,20万元

横向课题二:2018/09-2019/08,54万元

横向课题三:2017/02-2019/06,53万元

五、主要论文

1. You, B.;  Pan, S.;  Gu, M.;  Zhang, K.;  Xia, T.;  Zhang, S.;  Chen, W.;  Xie, H.;  Fan, Y.;  Yao, H.;  Cheng, T.;  Zhang, P.;  Liu, D.; You, Y., Extracellular vesicles rich in HAX1 promote angiogenesis by modulating ITGB6 translation. J Extracell Vesicles 2022, 11 (5), e12221. (通讯作者)

2. You, B.;  Xia, T.;  Gu, M.;  Zhang, Z.;  Zhang, Q.;  Shen, J.;  Fan, Y.;  Yao, H.;  Pan, S.;  Lu, Y.;  Cheng, T.;  Yang, Z.; He, X.;  Zhang, H.;  Shi, M.;  Liu, D.; You, Y., AMPK-mTOR-Mediated Activation of Autophagy Promotes Formation of Dormant Polyploid Giant Cancer Cells. Cancer Research 2022, 82 (5), 846-858. (通讯作者)

3. Li, N.;  Zhou, P.;  Tang, H.;  He, L.;  Fang, X.;  Zhao, J.;  Wang, X.;  Qi, Y.;  Sun, C.;  Lin, Y.;  Qin, F.;  Yang, M.; Zhang, Z.;  Liao, C.;  Zheng, S.;  Peng, X.;  Xue, T.;  Zhu, Q.;  Li, H.;  Li, Y.;  Liu, L.;  Huang, J.;  Liu, L.;  Peng, C.; Kaindl, A. M.;  Gecz, J.;  Han, D.;  Liu, D.;  Xu, K.; Hu, H., In-depth analysis reveals complex molecular aetiology in a cohort of idiopathic cerebral palsy. Brain 2021. (通讯作者)

4. Zhang, L.;  Gao, Y.;  Zhang, R.;  Sun, F.;  Cheng, C.;  Qian, F.;  Duan, X.;  Wei, G.;  Sun, C.;  Pang, X.;  Chen, P.;  Chai, R.;  Yang, T.;  Wu, H.; Liu, D., THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis. PLoS Genet 2020, 16 (8), e1008953. (通讯作者)

5. Shi, Y.;  Duan, X.;  Xu, G.;  Wang, X.;  Wei, G.;  Dong, S.;  Xie, G.; Liu, D., A ribosomal DNA-hosted microRNA regulates zebrafish embryonic angiogenesis. Angiogenesis 2019, 22 (2), 211-221. (通讯作者)

6. Bao, L.;  You, B.;  Shi, S.;  Shan, Y.;  Zhang, Q.;  Yue, H.;  Zhang, J.;  Zhang, W.;  Shi, Y.;  Liu, Y.;  Wang, X.;  Liu, D.; You, Y., Metastasis-associated miR-23a from nasopharyngeal carcinoma-derived exosomes mediates angiogenesis by repressing a novel target gene TSGA10. Oncogene 2018, 37 (21), 2873-2889. (通讯作者)

7. Wang, F.;  Liu, D.;  Zhang, R. R.;  Yu, L. W.;  Zhao, J. Y.;  Yang, X. Y.;  Jiang, S. S.;  Ma, D.;  Qiao, B.;  Zhang, F.;  Jin, L.;  Gui, Y. H.; Wang, H. Y., A TBX5 3'UTR variant increases the risk of congenital heart disease in the Han Chinese population. Cell discovery 2017, 3, 17026. (共同一作)

8. Wang, X.;  Ling, C. C.;  Li, L.;  Qin, Y.;  Qi, J.;  Liu, X.;  You, B.;  Shi, Y.;  Zhang, J.;  Jiang, Q.;  Xu, H.;  Sun, C.; You, Y.;  Chai, R.; Liu, D., MicroRNA-10a/10b represses a novel target gene mib1 to regulate angiogenesis. Cardiovascular research 2016, 110 (1), 140-50. (通讯作者)

9. Qi, J.;  Dong, Z.;  Shi, Y.;  Wang, X.;  Qin, Y.;  Wang, Y.; Liu, D., NgAgo-based fabp11a gene knockdown causes eye developmental defects in zebrafish. Cell research 2016, 26 (12), 1349-1352. (通讯作者)

10. 高煜,刘家辉,王新,刘东,斑马鱼遗传操作进展,生物工程学报2017, 33(10): 1674-1692 (通讯作者)


  

其他SCI论文:

 

1.   Zheng, Y. Q.;  Suo, G. H.;  Liu, D.;  Li, H. Y.;  Wu, Y. J.; Ni, H., Nexmifa Regulates Axon Morphogenesis in Motor Neurons in Zebrafish. Frontiers in molecular neuroscience 2022, 15, 848257. (通讯作者)

2.   Zheng, S.;  Tang, D.;  Wang, X.;  Liu, C.;  Zuo, N.;  Yan, R.;  Wu, C.;  Ma, J.;  Wang, C.;  Xu, H.;  He, Y.;  Liu, D.; Liu, S., Kif15 Is Required in the Development of Auditory System Using Zebrafish as a Model. Frontiers in molecular neuroscience 2022, 15, 844568. (通讯作者)

3.   Xu, G.;  Huang, Z.;  Sheng, J.;  Gao, X.;  Wang, X.;  Garcia, J. Q.;  Wei, G.;  Liu, D.; Gong, J., FGF binding protein 3 is required for spinal cord motor neuron development and regeneration in zebrafish. Exp Neurol 2022, 348, 113944. (通讯作者)

4.   Wei, G.;  Zhang, X.;  Cai, C.;  Sheng, J.;  Xu, M.;  Wang, C.;  Gu, Q.;  Guo, C.;  Chen, F.;  Liu, D.; Qian, F., Dual-Specificity Phosphatase 14 Regulates Zebrafish Hair Cell Formation Through Activation of p38 Signaling Pathway. Front Cell Neurosci 2022, 16, 840143. (通讯作者)

5.   Sheng, J.;  Xu, J.;  Geng, K.; Liu, D., Sema6D Regulates Zebrafish Vascular Patterning and Motor Neuronal Axon Growth in Spinal Cord. Frontiers in molecular neuroscience 2022, 15, 854556. (通讯作者)

6.   Sheng, J.;  Gong, J.;  Shi, Y.;  Wang, X.; Liu, D., MicroRNA-22 coordinates vascular and motor neuronal pathfinding via sema4 during zebrafish development. Open Biol 2022, 12 (4), 210315. (通讯作者)

7.   Qian, P.;  Kang, J.;  Liu, D.; Xie, G., Single Cell Transcriptome Sequencing of Zebrafish Testis Revealed Novel Spermatogenesis Marker Genes and Stronger Leydig-Germ Cell Paracrine Interactions. Front Genet 2022, 13, 851719. (通讯作者)

8.   Qian, F.;  Jiang, X.;  Chai, R.; Liu, D., The Roles of Solute Carriers in Auditory Function. Front Genet 2022, 13, 823049. (通讯作者)

9.   Lv, F.;  Ge, X.;  Qian, P.;  Lu, X.;  Liu, D.; Chen, C., Neuron navigator 3 (NAV3) is required for heart development in zebrafish. Fish physiology and biochemistry 2022. (通讯作者)

10. Hu, S. Q.;  Xu, H. M.;  Qian, F. P.;  Chen, C. S.;  Wang, X.;  Liu, D.; Cheng, L., Interferon regulatory factor-7 is required for hair cell development during zebrafish embryogenesis. Dev Neurobiol 2022, 82 (1), 88-97. (通讯作者)

11. Chen, C.; Liu, D., Establishment of Zebrafish Models for Diabetes Mellitus and Its Microvascular Complications. J Vasc Res 2022, 1-9. (通讯作者)

12. Zhou, J.;  Liang, W.;  Wang, J.;  Chen, J.;  Liu, D.;  Wang, X.;  Wu, Y.;  Zhang, Q.; Shen, D., An epileptic encephalopathy associated GABRG2 missense mutation leads to pre- and postsynaptic defects in zebrafish. Human molecular genetics 2021.

13. Zheng, Y.;  Zhao, J.;  Li, J.;  Guo, Z.;  Sheng, J.;  Ye, X.;  Jin, G.;  Wang, C.;  Chai, W.;  Yan, J.;  Liu, D.; Liang, X., SARS-CoV-2 spike protein causes blood coagulation and thrombosis by competitive binding to heparan sulfate. Int J Biol Macromol 2021, 193 (Pt B), 1124-1129. (通讯作者)

14. Zhang, K.;  Liu, D.;  Zhao, J.;  Shi, S.;  He, X.;  Da, P.;  You, Y.; You, B., Nuclear exosome HMGB3 secreted by nasopharyngeal carcinoma cells promotes tumour metastasis by inducing angiogenesis. Cell Death Dis 2021, 12 (6), 554. (共同一作)

15. Xie, G.;  Zhang, X.;  Lv, F.;  Sang, M.;  Hu, H.;  Wang, J.; Liu, D., Nanopore Sequencing and Hi-C Based De Novo Assembly of Trachidermus fasciatus Genome. Genes (Basel) 2021, 12 (5). (通讯作者)

16. Shi, L.;  Chen, C.;  Yin, Z.;  Wei, G.;  Xie, G.; Liu, D., Systematic profiling of early regulators during tissue regeneration using zebrafish model. Wound Repair Regen 2021, 29 (1), 189-195. (通讯作者)

17. Pang, X. H.;  Zheng, X. Y.;  Lin, Y.;  Zheng, H.;  Xu, J.;  Liu, D.;  Jin, C. Y.;  Zhang, L. P.;  Zhang, Y. T.;  Chu, J. S.;  Chai, Y. C.; Yang, T., A Novel p.Tyr129His Variant in SIX1 Leads to Dominant, Delayed-onset Hearing Loss with Possible Association with Congenital Anosmia. Biomed Environ Sci 2021, 34 (4), 314-318.

18. Li, M.;  Liu, J.;  Liu, D.;  Duan, X.;  Zhang, Q.;  Wang, D.;  Zheng, Q.;  Bai, X.; Lu, Z., Naringin attenuates cisplatin- and aminoglycoside-induced hair cell injury in the zebrafish lateral line via multiple pathways. J Cell Mol Med 2021, 25 (2), 975-989.

19. Hu, Z.;  Zhang, C.;  Wang, S.;  Gao, S.;  Wei, J.;  Li, M.;  Hou, L.;  Mao, H.;  Wei, Y.;  Qi, T.;  Liu, H.;  Liu, D.;  Lan, F.;  Lu, D.;  Wang, H.;  Li, J.; Wang, Y., Discovery and engineering of small SlugCas9 with broad targeting range and high specificity and activity. Nucleic acids research 2021, 49 (7), 4008-4019.

20. Gong, J.;  Qian, P.;  Hu, Y.;  Guo, C.;  Wei, G.;  Wang, C.;  Cai, C.;  Wang, H.; Liu, D., Claudin h Is Essential for Hair Cell Morphogenesis and Auditory Function in Zebrafish. Front Cell Dev Biol 2021, 9, 663995. (通讯作者)

21. Zhang, Z.;  Hou, H.;  Yu, S.;  Zhou, C.;  Zhang, X.;  Li, N.;  Zhang, S.;  Song, K.;  Lu, Y.;  Liu, D.;  Lu, H.; Xu, H., Inflammation-induced mammalian target of rapamycin signaling is essential for retina regeneration. Glia 2020, 68 (1), 111-127.

22. Zhang, Y.;  Wang, Y.;  Yao, X.;  Wang, C.;  Chen, F.;  Liu, D.;  Shao, M.; Xu, Z., Rbm24a Is Necessary for Hair Cell Development Through Regulating mRNA Stability in Zebrafish. Front Cell Dev Biol 2020, 8, 604026.

23. Wang, B.;  Xu, M.;  Li, M.;  Wu, F.;  Hu, S.;  Chen, X.;  Zhao, L.;  Huang, Z.;  Lan, F.;  Liu, D.; Wang, Y., miR-25 Promotes Cardiomyocyte Proliferation by Targeting FBXW7. Mol Ther Nucleic Acids 2020, 19, 1299-1308.

24. Shen, D.;  Chen, J.;  Liu, D.;  Shen, M.;  Wang, X.;  Wu, Y.;  Ke, S.;  Macdonald, R. L.; Zhang, Q., The GABRG2 F343L allele causes spontaneous seizures in a novel transgenic zebrafish model that can be treated with suberanilohydroxamic acid (SAHA). Ann Transl Med 2020, 8 (23), 1560.

25. Qian, F.;  Wang, X.;  Yin, Z.;  Xie, G.;  Yuan, H.;  Liu, D.; Chai, R., The slc4a2b gene is required for hair cell development in zebrafish. Aging (Albany NY) 2020, 12 (19), 18804-18821. (通讯作者)

26. Liu, C.;  Zhao, J.;  Zhang, X.;  Wei, G.;  Hao, W.;  Wang, X.;  Yang, C.;  Shi, Y.; Liu, D., Biomass-derived cellulose nanoparticles display considerable neurotoxicity in zebrafish. Int J Biol Macromol 2020, 165 (Pt B), 1783-1792. (通讯作者)

27. Hu, Z.;  Wang, S.;  Zhang, C.;  Gao, N.;  Li, M.;  Wang, D.;  Wang, D.;  Liu, D.;  Liu, H.;  Ong, S. G.;  Wang, H.; Wang, Y., A compact Cas9 ortholog from Staphylococcus Auricularis (SauriCas9) expands the DNA targeting scope. PLoS Biol 2020, 18 (3), e3000686.

28. Gong, J.;  Hu, S.;  Huang, Z.;  Hu, Y.;  Wang, X.;  Zhao, J.;  Qian, P.;  Wang, C.;  Sheng, J.;  Lu, X.;  Wei, G.; Liu, D., The Requirement of Sox2 for the Spinal Cord Motor Neuron Development of Zebrafish. Frontiers in molecular neuroscience 2020, 13, 34. (通讯作者)

29. Gao, C.;  Guo, C.;  Peng, Q.;  Cao, J.;  Shohat-Ophir, G.;  Liu, D.; Pan, Y., Sex and Death: Identification of Feedback Neuromodulation Balancing Reproduction and Survival. Neuroscience bulletin 2020, 36 (12), 1429-1440.

30. Zhang, K.;  Zhang, H.;  Zhou, H.;  Crookes, D.;  Li, L.;  Shao, Y.; Liu, D., Zebrafish Embryo Vessel Segmentation Using a Novel Dual ResUNet Model. Comput Intell Neurosci 2019, 2019, 8214975. (通讯作者)

31. Zhang, H.;  Gao, Y.;  Qian, P.;  Dong, Z.;  Hao, W.;  Liu, D.; Duan, X., Expression analysis of Rab11 during zebrafish embryonic development. BMC Dev Biol 2019, 19 (1), 25.

32. Yu, B.;  Yao, C.;  Wang, Y.;  Mao, S.;  Wang, Y.;  Wu, R.;  Feng, W.;  Chen, Y.;  Yang, J.;  Xue, C.;  Liu, D.; Ding, F.; Gu, X., The Landscape of Gene Expression and Molecular Regulation Following Spinal Cord Hemisection in Rats. Frontiers in molecular neuroscience 2019, 12, 287.

33. Wang, Y. M.;  Zheng, Y. F.;  Yang, S. Y.;  Yang, Z. M.;  Zhang, L. N.;  He, Y. Q.;  Gong, X. H.;  Liu, D.;  Finnell, R. H.;  Qiu, Z. L.;  Du, Y. S.; Wang, H. Y., MicroRNA-197 controls ADAM10 expression to mediate MeCP2's role in the differentiation of neuronal progenitors. Cell Death Differ 2019, 26 (10), 1863-1879.

34. Wang, D.;  Zhang, C.;  Wang, B.;  Li, B.;  Wang, Q.;  Liu, D.;  Wang, H.;  Zhou, Y.;  Shi, L.;  Lan, F.; Wang, Y., Optimized CRISPR guide RNA design for two high-fidelity Cas9 variants by deep learning. Nat Commun 2019, 10 (1), 4284.

35. Shi, Y.;  Wang, X.;  Shi, Y.;  Zhang, J.;  Zhao, S.;  Yin, Z.;  Xu, G.;  Duan, X.;  Guo, Z.;  Liang, X.; Liu, D., Two Compounds Isolated From Ganglioside GM1 Promote Angiogenesis in Zebrafish. J Cardiovasc Pharmacol 2019, 74 (1), 71-79. (通讯作者)

36. Qin, Y.;  Wang, S.;  Duan, X.; Liu, D., Expression analysis of the aquaporins during zebrafish embryonic development. Gene expression patterns : GEP 2019, 32, 38-43. (通讯作者)

37. Li, L.;  Zhu, M.;  Wu, W.;  Qin, B.;  Gu, J.;  Tu, Y.;  Chen, J.;  Liu, D.;  Shi, Y.;  Liu, X.;  Sang, A.; Ding, D., Brivanib, a multitargeted small-molecule tyrosine kinase inhibitor, suppresses laser-induced CNV in a mouse model of neovascular AMD. J Cell Physiol 2019.

38. Dong, Z.;  Wu, S.;  Zhu, C.;  Wang, X.;  Li, Y.;  Chen, X.;  Liu, D.;  Qiang, L.;  Baas, P. W.; Liu, M., Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9-mediated kif15 mutations accelerate axonal outgrowth during neuronal development and regeneration in zebrafish. Traffic 2019, 20 (1), 71-81.

39. Yan, W.;  Liu, W.;  Qi, J.;  Fang, Q.;  Fan, Z.;  Sun, G.;  Han, Y.;  Zhang, D.;  Xu, L.;  Wang, M.;  Li, J.;  Chen, F.;  Liu, D.;  Chai, R.; Wang, H., A Three-Dimensional Culture System with Matrigel Promotes Purified Spiral Ganglion Neuron Survival and Function In Vitro. Molecular neurobiology 2018, 55 (3), 2070-2084. (通讯作者)

40. Shan, Y.;  You, B.;  Shi, S.;  Shi, W.;  Zhang, Z.;  Zhang, Q.;  Gu, M.;  Chen, J.;  Bao, L.;  Liu, D.; You, Y., Hypoxia-Induced Matrix Metalloproteinase-13 Expression in Exosomes from Nasopharyngeal Carcinoma Enhances Metastases. Cell Death Dis 2018, 9 (3), 382. (通讯作者)

41. Li, B.;  Yu, L.;  Liu, D.;  Yang, X.;  Zheng, Y.;  Gui, Y.; Wang, H., MIB1 Mutations Reduce Notch Signaling Activation and Contribute to Congenital Heart Disease. Clin Sci (Lond) 2018.

42. Gong, J.;  Chai, L.;  Xu, G.;  Ni, Y.; Liu, D., The expression of natriuretic peptide receptors in developing zebrafish embryos. Gene expression patterns : GEP 2018, 29, 65-71. (通讯作者)

43. Zhang, J.;  Qi, J.;  Wu, S.;  Peng, L.;  Shi, Y.;  Yang, J.;  Yin, Z.;  Gao, Y.;  Wang, C.;  Gong, J.;  Zhang, H.;  Zhang, J.; Liu, D., Fatty Acid Binding Protein 11a Is Required for Brain Vessel Integrity in Zebrafish. Frontiers in physiology 2017, 8, 214. (通讯作者)

44. Xie, Y.;  Wang, D.;  Lan, F.;  Wei, G.;  Ni, T.;  Chai, R.;  Liu, D.;  Hu, S.;  Li, M.;  Li, D.;  Wang, H.; Wang, Y., An episomal vector-based CRISPR/Cas9 system for highly efficient gene knockout in human pluripotent stem cells. Scientific reports 2017, 7 (1), 2320.

45. Mu, Z.;  Zhang, S.;  He, C.;  Hou, H.;  Liu, D.;  Hu, N.; Xu, H., Expression of SoxC Transcription Factors during Zebrafish Retinal and Optic Nerve Regeneration. Neuroscience bulletin 2017, 33 (1), 53-61.

46. Lv, F.;  Zhu, C.;  Yan, X.;  Wang, X.; Liu, D., Generation of a mef2aa:EGFP transgenic zebrafish line that expresses EGFP in muscle cells. Fish physiology and biochemistry 2017, 43 (1), 287-294. (通讯作者)

47. Jin, D.;  Zhu, D.;  Fang, Y.;  Chen, Y.;  Yu, G.;  Pan, W.;  Liu, D.;  Li, F.; Zhong, T. P., Vegfa signaling regulates diverse artery/vein formation in vertebrate vasculatures. Journal of genetics and genomics 2017, 44 (10), 483-492.

48. He, Z.;  Guo, L.;  Shu, Y.;  Fang, Q.;  Zhou, H.;  Liu, Y.;  Liu, D.;  Lu, L.;  Zhang, X.;  Ding, X.;  Liu, D.;  Tang, M.;  Kong, W.;  Sha, S.;  Li, H.;  Gao, X.; Chai, R., Autophagy protects auditory hair cells against neomycin-induced damage. Autophagy 2017, 1-21.

49. He, Y.;  Lu, X.;  Qian, F.;  Liu, D.;  Chai, R.; Li, H., Insm1a Is Required for Zebrafish Posterior Lateral Line Development. Frontiers in molecular neuroscience 2017, 10, 241.

50. Gong, J.;  Wang, X.;  Zhu, C.;  Dong, X.;  Zhang, Q.;  Wang, X.;  Duan, X.;  Qian, F.;  Shi, Y.;  Gao, Y.;  Zhao, Q.;  Chai, R.; Liu, D., Insm1a Regulates Motor Neuron Development in Zebrafish. Frontiers in molecular neuroscience 2017, 10, 274. (通讯作者)

51. Zhang, S.;  Mu, Z.;  He, C.;  Zhou, M.;  Liu, D.;  Zhao, X. F.;  Goldman, D.; Xu, H., Antiviral Drug Ganciclovir Is a Potent Inhibitor of the Proliferation of Muller Glia-Derived Progenitors During Zebrafish Retinal Regeneration. Investigative ophthalmology & visual science 2016, 57 (4), 1991-2000.

52. Wang, X.;  Yuan, W.;  Wang, X.;  Qi, J.;  Qin, Y.;  Shi, Y.;  Zhang, J.;  Gong, J.;  Dong, Z.;  Liu, X.;  Sun, C.;  Chai, R.;  Le Noble, F.; Liu, D., The somite-secreted factor Maeg promotes zebrafish embryonic angiogenesis. Oncotarget2016, 7 (47), 77749-77763. (通讯作者)

53. Shi, Y. W.;  Yuan, W.;  Wang, X.;  Gong, J.;  Zhu, S. X.;  Chai, L. L.;  Qi, J. L.;  Qin, Y. Y.;  Gao, Y.;  Zhou, Y. L.;  Fan, X. L.;  Ji, C. Y.;  Wu, J. Y.;  Wang, Z. W.; Liu, D., Combretastatin A-4 efficiently inhibits angiogenesis and induces neuronal apoptosis in zebrafish. Scientific reports 2016, 6, 30189. (通讯作者) 

54. He, Z.;  Zhang, S.;  Song, Q.;  Li, W.;  Liu, D.;  Li, H.;  Tang, M.; Chai, R., The structural development of primary cultured hippocampal neurons on a graphene substrate. Colloids and surfaces. B, Biointerfaces 2016, 146, 442-51.

55. Wang, X.;  Wang, X.;  Yuan, W.;  Chai, R.; Liu, D., Egfl6 is involved in zebrafish notochord development. Fish physiology and biochemistry 2015, 41 (4), 961-9. (通讯作者)

56. Wang, X.;  Chong, M.;  Wang, X.;  Wang, H.;  Zhang, J.;  Xu, H.;  Zhang, J.; Liu, D., Block the function of nonmuscle myosin II by blebbistatin induces zebrafish embryo cardia bifida. In vitro cellular & developmental biology. Animal 2015, 51 (3), 211-7.

57. Xu, M.;  Liu, D.;  Dong, Z.;  Wang, X.;  Wang, X.;  Liu, Y.;  Baas, P. W.; Liu, M., Kinesin-12 influences axonal growth during zebrafish neural development. Cytoskeleton 2014, 71 (10), 555-63.

58. Wang, X.;  Li, L.; Liu, D., Expression analysis of integrin beta1 isoforms during zebrafish embryonic development. Gene expression patterns : GEP 2014, 16 (2), 86-92. (通讯作者)

59. Sang, Q.;  Zhang, J.;  Feng, R.;  Wang, X.;  Li, Q.;  Zhao, X.;  Xing, Q.;  Chen, W.;  Du, J.;  Sun, S.;  Chai, R.;  Liu, D.;  Jin, L.;  He, L.;  Li, H.; Wang, L., Ildr1b is essential for semicircular canal development, migration of the posterior lateral line primordium and hearing ability in zebrafish: implications for a role in the recessive hearing impairment DFNB42. Human molecular genetics 2014, 23 (23), 6201-11.

60. Li, S.;  Liu, Q.;  Wang, Y.;  Gu, Y.;  Liu, D.;  Wang, C.;  Ding, G.;  Chen, J.;  Liu, J.; Gu, X., Differential gene expression profiling and biological process analysis in proximal nerve segments after sciatic nerve transection. PLoS One 2013, 8 (2), e57000.

61. Jiang, Q.;  Lagos-Quintana, M.;  Liu, D.;  Shi, Y.;  Helker, C.;  Herzog, W.; le Noble, F., miR-30a regulates endothelial tip cell formation and arteriolar branching. Hypertension 2013, 62 (3), 592-8.

62. Huang, Y.;  Wang, X.;  Xu, M.;  Liu, M.; Liu, D., Nonmuscle myosin II-B (myh10) expression analysis during zebrafish embryonic development. Gene expression patterns : GEP 2013, 13 (7), 265-70.

63. Liu, D.;  Krueger, J.; Le Noble, F., The role of blood flow and microRNAs in blood vessel development. Int J Dev Biol 2011, 55 (4-5), 419-29.

64. Krueger, J.;  Liu, D.;  Scholz, K.;  Zimmer, A.;  Shi, Y.;  Klein, C.;  Siekmann, A.;  Schulte-Merker, S.;  Cudmore, M.;  Ahmed, A.; le Noble, F., Flt1 acts as a negative regulator of tip cell formation and branching morphogenesis in the zebrafish embryo. Development 2011, 138 (10), 2111-20.

65. Klein, C.;  Mikutta, J.;  Krueger, J.;  Scholz, K.;  Brinkmann, J.;  Liu, D.;  Veerkamp, J.;  Siegel, D.;  Abdelilah-Seyfried, S.; le Noble, F., Neuron navigator 3a regulates liver organogenesis during zebrafish embryogenesis. Development 2011, 138 (10), 1935-45.

66. Jiang, Q.;  Liu, D.;  Sun, S.;  Hu, J.;  Tan, L.;  Wang, Y.;  Gui, Y.;  Yu, M.; Song, H., Critical role of connexin43 in zebrafish late primitive and definitive hematopoiesis. Fish physiology and biochemistry 2010, 36 (4), 945-51.

67. Jiang, Q.;  Liu, D.;  Gong, Y.;  Wang, Y.;  Sun, S.;  Gui, Y.; Song, H., yap is required for the development of brain, eyes, and neural crest in zebrafish. Biochem Biophys Res Commun 2009, 384 (1), 114-9.

68. Liu, D.;  Wang, Y. X.;  Hu, J. Y.;  Sun, S. N.; Song, H. Y., The effects of connexin43 down regulation on the development of the embryonic heart and vasculature in zebrafish. Progress in Biochemistry and Biophysics 2008, 35 (7), 766-771.

69. Wang, Y. X.;  Qian, L. X.;  Liu, D.;  Yao, L. L.;  Jiang, Q.;  Yu, Z.;  Gui, Y. H.;  Zhong, T. P.; Song, H. Y., Bone morphogenetic protein-2 acts upstream of myocyte-specific enhancer factor 2a to control embryonic cardiac contractility. Cardiovascular research 2007, 74 (2), 290-303. 

70. Sun, S. N.;  Gui, Y. H.;  Wang, Y. X.;  Qian, L. X.;  Jiang, Q.;  Liu, D.; Song, H. Y., Effect of dihydrofolate reductase gene knock-down on the expression of heart and neural crest derivatives expressed transcript 2 in zebrafish cardiac development. Chin Med J (Engl) 2007, 120 (13), 1166-71.

 

 

中文论文:

 

1. 张晶晶,王新,刘东,C型利钠肽基因调控斑马鱼胚胎血管发育,生理学报,2017, 69(1): 1116 (通讯作者)

2. 吕峰,石运伟,王新,刘东,严兴洪,microRNA-10a/b通过抑制Mib1调节斑马鱼神经元的发育,中国细胞生物学学报,2017, 39(2): 191196 (通讯作者)

3. 王鸿奎,王学谦,王新,袁玮,刘东,非肌性肌球蛋白II-B调节斑马鱼咽弓的发育解剖学报,2016, 47(1):113-116 (通讯作者)

4. 袁玮,浦超,Rupesh Puri,石运伟,王新,李石营,刘东,Non-muscle Myosin II-A调节斑马鱼胚胎发育过程中肠内分泌细胞的极化,中国细胞生物学报,2015, 37(3): 328334 (通讯作者)

5. 王新,张素珍,王学谦,李丽萍,张晶晶,刘东,流式细胞仪分选转基因斑马鱼胚胎荧光标记细胞的一种快速方法,中国细胞生物学报,2014, 36(3): 356360 (通讯作者)

6. 刘雪静,王雪雯,石运伟,王新,高煜,刘东,生长激素促进斑马鱼尾鳍的再生,中国实验动物学报,2019, 27(2): 154159 (通讯作者)

  


联系方式以及其它信息

Email: liudongtom@gmail.com