魏官云 博士，讲师

weiguanyun@ntu.edu.cn

         2018年博士毕业于南京师范大学动物学专业，主要从事生物信息学研究。毛细胞发育与功能、基因调控网络、多组学数据整合与分析等。主持国家自然科学基金青年项目、江苏省青年科技项目、南通市科技项目、江苏省学术学位创新项目，并参与多项科研项目研究。发表多篇SCI论文。

 发表文章： 

1.     Wei G, Zhang X, Cai C, et al. Dual-Specificity Phosphatase 14 Regulates Zebrafish Hair Cell Formation Through Activation of p38 Signaling Pathway[J]. Frontiers in Cellular Neuroscience, 2022, 16.

2.     Qian F^#, Wei G^#, Gao Y, et al. Single-cell RNA-sequencing of zebrafish hair cells reveals novel genes potentially involved in hearing loss. Cell Mol Life Sci. 2022 Jun 26;79(7):385.

3.     Zhao J^#, Wei G^#, Zhu J, Liu D, Qin B. Expression analysis of nel during zebrafish embryonic development. Gene Expr Patterns. 2022 Sep;45:119258. doi: 10.1016/j.gep.2022.119258. Epub 2022 Jun 9. PMID: 35691514.

4.     Gong, J., Hu, S., Huang, Z., Hu, Y., Wang X., Zhao, J., Qian P., Wang C., Sheng J., Lu X., Wei G.*, Liu D.*. The requirement of Sox2 for the spinal cord motor neuron development of zebrafish. Frontiers in Molecular Neuroscience, 2020 March 27, 13, 34.

5.     Wei G^#, Sun L^#, Qin S, Li R, Chen L, Jin P, Ma F*. Dme-Hsa Disease Database (DHDD): Conserved Human Disease-Related miRNA and Their Targeting Genes in Drosophila melanogaster. Int J Mol Sci. 2018 Sep 6;19(9). pii: E2642. doi: 10.3390/ijms19092642.

6.     Guanyun Wei, Lianjie Sun, Ruimin Li, Lei li, Jiao Xu, Fei Ma*. Dynamic miRNA-mRNA regulations are essential for maintaining Drosophila immune homeostasis during Micrococcus luteus infection. Developmental and comparative immunology, doi: 10.1016/j.dci.2017.11.019, Apr, 2018, 81:210-224.

7.     Guanyun Wei, Sheng Qin, Wenjuan Li, Liming Chen, Fei Ma*. MDTE DB: a database for microRNAs derived from Transposable element. IEEE/ACM Transactions on Computational Biology and Bioinformatics, Volume: 13, Issue: 6, Nov.-Dec. 1 2016,1155-1160. 

8.     魏官云,邢永强,蔡禄*. 人类剪接因子与转录因子的互作网络构建与分析.生物物理学报, 2014年03期:238-246. 

9.     Chen Q, Xie H, Wei G, Guo X, Zhang J, Lu X, Tang Z. Metabolic differences of two constructive species in saline-alkali grassland in China. BMC Plant Biol. 2022 Jan 26;22(1):53. doi: 10.1186/s12870-021-03401-y. 

10.   Xu G, Huang Z, Sheng J, Gao X, Wang X, Garcia JQ, Wei G, Liu D, Gong J. FGF binding protein 3 is required for spinal cord motor neuron development and regeneration in zebrafish. Exp Neurol. 2022 Feb;348:113944. doi: 10.1016/j.expneurol.2021.113944.

11.   Gong J, Qian P, Hu Y, Guo C, Wei G, Wang C, Cai C, Wang H, Liu D. Claudin h Is Essential for Hair Cell Morphogenesis and Auditory Function in Zebrafish. Front Cell Dev Biol. 2021 May 11;9:663995. doi: 10.3389/fcell.2021.663995. 

12.   Chen Q, Jin Y, Zhang Z, Cao M, Wei G, Guo X, Zhang J, Lu X, Tang Z. Ionomic and Metabolomic Analyses Reveal Different Response Mechanisms to Saline-Alkali Stress Between Suaeda salsa Community and Puccinellia tenuiflora Community. Front Plant Sci. 2021 Nov 30;12:774284. doi: 10.3389/fpls.2021.774284.

13.   Shi L, Chen C, Yin Z, Wei G, Xie G, Liu D. Systematic profiling of early regulators during tissue regeneration using zebrafish model. Wound Repair Regen. 2021 Jan;29(1):189-195. doi: 10.1111/wrr.12852.

14.   Xue L, Chen F, Yue F, Camacho L, Kothapalli S, Wei G, Huang S, Mo Q, Ma F, Li Y, Jiralerspong S. Metformin and an insulin/IGF-1 receptor inhibitor are synergistic in blocking growth of triple-negative breast cancer. Breast Cancer Res Treat. 2021 Jan;185(1):73-84. doi: 10.1007/s10549-020-05927-5. 

15.   Liu C, Zhao J, Zhang X, Wei G, Hao W, Wang X, Yang C, Shi Y, Liu D. Biomass-derived cellulose nanoparticles display considerable neurotoxicity in zebrafish. Int J Biol Macromol. 2020 Dec 15;165(Pt B):1783-1792. doi: 10.1016/j.ijbiomac.2020.10.033.

16.   Gao S, Zhang K, Wei L, Wei G, Xiong W, Lu Y, Zhang Y, Gao A, Li B. Insecticidal Activity of Artemisia vulgaris Essential Oil and Transcriptome Analysis of Tribolium castaneum in Response to Oil Exposure. Front Genet. 2020 Jun 25;11:589. doi: 10.3389/fgene.2020.00589. 

17.   Yunwei Shi, Peipei Qian, Jiajing Sheng, Xu Zhang, Xiaoning Wang, Jingxiang Zhao, Guanyun Wei, Xia Liu, Gangcai Xie, Dong Liu*. Single-cell RNA-seq reveals endoimmune cells in zebrafish. bioRxiv, 2020, doi.org/10.1101/2019.12.31.892240.

18.   Luping Zhang, Yu Gao, Ru Zhang, Feifei Sun, Cheng Cheng, Fuping Qian, Xuchu Duan, Guanyun Wei, Xiuhong Pang, Penghui Chen, Renjie Chai, Tao Yang, Hao Wu, Dong Liu*. THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis. bioRxiv, 2019 July 30, doi: https://doi.org/10.1101/719823.

19.   Zhang X*, Liu X, Li L, Wei G, Zhang D, Liang Y, Miao B. Phylogeny, Divergent Evolution, and Speciation of Sulfur-Oxidizing Acidithiobacillus Populations. BMC Genomics. 2019 May 30;20(1):438. doi: 10.1186/s12864-019-5827-6.

20.   Shi Y, Duan X, Xu G, Wang X, Wei G, Dong S, Xie G, Liu D*. A ribosomal DNA-hosted microRNA regulates zebrafish embryonic angiogenesis. Angiogenesis. 2019 May;22(2):211-221. doi: 10.1007/s10456-019-09663-3. Epub 2019 Jan 17.

21.   Gong X, Liu W, Wu L, Ma Z, Wang Y, Yu S, Zhang J, Xie H, Wei G, Ma F, Lu L, Chen L*. Transcriptional repressor GATA binding 1-mediated repression of SRY-box 2 expression suppresses cancer stem cell functions and tumor initiation. J Biol Chem. 2018 Nov 30;293(48):18646-18654. doi: 10.1074/jbc.RA118.003983. Epub 2018 Oct 12.

22.   Wang Y, Zhang J, Wu L, Liu W, Wei G, Gong X, Liu Y, Ma Z, Ma F, Thiery JP, Chen L*. Tricho-rhino-phalangeal syndrome 1 protein functions as a scaffold required for ubiquitin-specific protease 4-directed histone deacetylase 2 de-ubiquitination and tumor growth. Breast Cancer Res. 2018 Aug 2;20(1):83. doi: 10.1186/s13058-018-1018-7.

23.   Zhang X, Liu Z, Wei G, Yang F, Liu X*. In Silico Genome-Wide Analysis Reveals the Potential Links Between Core Genome of Acidithiobacillus thiooxidans and Its Autotrophic Lifestyle. Front Microbiol. 2018 Jun 8;9:1255. doi: 10.3389/fmicb.2018.01255. eCollection 2018.

24.   Xing Y, Zhao X, Yu T, Liang D, Li J, Wei G, Liu G, Cui X, Zhao H, Cai L. MiasDB: A Database of Molecular Interactions Associated with Alternative Splicing of Human Pre-mRNAs. PLoS One. 2016 May 11;11(5):e0155443. doi: 10.1371/journal.pone.0155443. eCollection 2016.