组织器官发育和相关疾病的遗传调控团队
科研团队:组织器官发育和相关疾病的遗传调控
团队网站：/ldsys/main.htm
团队简介：
亚博赞助阿根廷球队“组织器官发育和相关疾病的遗传调控”团队的主要研究方向为：1、生理和病理条件下血管新生的遗传调控；2、神经发育以及相关疾病的发病机制；3、基于血管内皮细胞、毛细胞和运动神经元行为的化合物筛选。团队在模式生物斑马鱼和小鼠模型上，利用多种遗传操作技术、活体成像、高通量测序等手段探索相关疾病的发病机制和干预的理论依据。
二、团队负责人简介：
刘东 博士, 教授, 博士生导师。江苏省杰出青年基金获得者、江苏省第五期“333高层次人才培养工程”培养对象、江苏省“六大人才高峰”高层次人才培养对象、获江苏省“双创计划”资助。他是美国心脏协会American Heart Association会员，中国解剖学会再生医学专业委员会委员，中国生物物理学会听觉分会委员，青年委员会常务委员。近三年来发表SCI论文30篇，累计影响因子超过130，其中以通讯作者发表SCI 论文20篇，其中包括知名杂志CardiovascularResearch、Cell Research和Oncogene等。近5年来以项目主持人身份获得共10项国家级、省部级科研以及人才项目资助。
三、团队成员：
石运伟 博士、助理研究员（神经再生重点实验室）
王新 实验师（神经再生重点实验室）
巩杰 博士，副教授，硕士生导师
段叙初 博士、讲师
魏官云 博士、讲师
蔡成芸 博士、讲师
王琤博士、讲师
卢晓凤 博士、讲师
郝文璟 博士、讲师
研究生：
钱付平
王晓宁
钱佩佩
赵金湘
徐梦婷
张旭
黄自刚
胡越波
客座研究人员：
秦银银（宿迁第一人民医院）
吕峰 博士（南通科技学院）
四、在研课题
2019-2022: 国家自然科学基金-面上项目：血管新生的遗传调控（刘东）
2016-2019: 国家自然科学基金-面上项目：血管新生的遗传调控（刘东）
2013-2015: 国家自然科学基金-青年项目：血管新生的遗传调控（刘东）
2018-2021: 江苏省自然科学基金-杰出青年基金项目：血管新生的遗传调控（刘东）
2012-2015: 江苏省自然科学基金-青年基金项目：血管新生的遗传调控（刘东）
2017-2020: 江苏省高校自然科学研究项目-重大项目：血管新生（刘东）
2016-2019: 江苏省“六大人才高峰”高层次人才培养对象：血管新生（刘东）
2014-2016: 江苏省“双创计划”博士计划，境外世界名校创新类计划（刘东）
2012-2014: 江苏省高校自然科学研究项目-面上项目：血管新生（刘东）
石运伟：国家自然科学基金-面上项目：
王新：国家自然科学基金-青年项目
巩杰：国家自然科学基金-青年项目
段旭初：国家自然科学基金-青年项目
魏官云：江苏省自然科学基金-青年基金项目
巩杰：江苏省自然科学基金-青年基金项目
段旭初：江苏省高校自然科学研究项目-面上项目
横向课题一：2018/08-2018/12，20万元
横向课题二：2018/09-2019/08，54万元
横向课题三：2017/02-2019/06，53万元
五、主要论文
1. You, B.; Pan, S.; Gu, M.; Zhang, K.; Xia, T.; Zhang, S.; Chen, W.; Xie, H.; Fan, Y.; Yao, H.; Cheng, T.; Zhang, P.; Liu, D.; You, Y., Extracellular vesicles rich in HAX1 promote angiogenesis by modulating ITGB6 translation. J Extracell Vesicles 2022, 11 (5), e12221. (通讯作者)
2. You, B.; Xia, T.; Gu, M.; Zhang, Z.; Zhang, Q.; Shen, J.; Fan, Y.; Yao, H.; Pan, S.; Lu, Y.; Cheng, T.; Yang, Z.; He, X.; Zhang, H.; Shi, M.; Liu, D.; You, Y., AMPK-mTOR-Mediated Activation of Autophagy Promotes Formation of Dormant Polyploid Giant Cancer Cells. Cancer Research 2022, 82 (5), 846-858. (通讯作者)
3. Li, N.; Zhou, P.; Tang, H.; He, L.; Fang, X.; Zhao, J.; Wang, X.; Qi, Y.; Sun, C.; Lin, Y.; Qin, F.; Yang, M.; Zhang, Z.; Liao, C.; Zheng, S.; Peng, X.; Xue, T.; Zhu, Q.; Li, H.; Li, Y.; Liu, L.; Huang, J.; Liu, L.; Peng, C.; Kaindl, A. M.; Gecz, J.; Han, D.; Liu, D.; Xu, K.; Hu, H., In-depth analysis reveals complex molecular aetiology in a cohort of idiopathic cerebral palsy. Brain 2021. (通讯作者)
4. Zhang, L.; Gao, Y.; Zhang, R.; Sun, F.; Cheng, C.; Qian, F.; Duan, X.; Wei, G.; Sun, C.; Pang, X.; Chen, P.; Chai, R.; Yang, T.; Wu, H.; Liu, D., THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis. PLoS Genet 2020, 16 (8), e1008953. (通讯作者)
5. Shi, Y.; Duan, X.; Xu, G.; Wang, X.; Wei, G.; Dong, S.; Xie, G.; Liu, D., A ribosomal DNA-hosted microRNA regulates zebrafish embryonic angiogenesis. Angiogenesis 2019, 22 (2), 211-221. (通讯作者)
6. Bao, L.; You, B.; Shi, S.; Shan, Y.; Zhang, Q.; Yue, H.; Zhang, J.; Zhang, W.; Shi, Y.; Liu, Y.; Wang, X.; Liu, D.; You, Y., Metastasis-associated miR-23a from nasopharyngeal carcinoma-derived exosomes mediates angiogenesis by repressing a novel target gene TSGA10. Oncogene 2018, 37 (21), 2873-2889. (通讯作者)
7. Wang, F.; Liu, D.; Zhang, R. R.; Yu, L. W.; Zhao, J. Y.; Yang, X. Y.; Jiang, S. S.; Ma, D.; Qiao, B.; Zhang, F.; Jin, L.; Gui, Y. H.; Wang, H. Y., A TBX5 3'UTR variant increases the risk of congenital heart disease in the Han Chinese population. Cell discovery 2017, 3, 17026. (共同一作)
8. Wang, X.; Ling, C. C.; Li, L.; Qin, Y.; Qi, J.; Liu, X.; You, B.; Shi, Y.; Zhang, J.; Jiang, Q.; Xu, H.; Sun, C.; You, Y.; Chai, R.; Liu, D., MicroRNA-10a/10b represses a novel target gene mib1 to regulate angiogenesis. Cardiovascular research 2016, 110 (1), 140-50. (通讯作者)
9. Qi, J.; Dong, Z.; Shi, Y.; Wang, X.; Qin, Y.; Wang, Y.; Liu, D., NgAgo-based fabp11a gene knockdown causes eye developmental defects in zebrafish. Cell research 2016, 26 (12), 1349-1352. (通讯作者)
10. 高煜，刘家辉，王新，刘东，斑马鱼遗传操作进展，生物工程学报，2017, 33(10): 1674-1692 (通讯作者)
其他SCI论文：
1. Zheng, Y. Q.; Suo, G. H.; Liu, D.; Li, H. Y.; Wu, Y. J.; Ni, H., Nexmifa Regulates Axon Morphogenesis in Motor Neurons in Zebrafish. Frontiers in molecular neuroscience 2022, 15, 848257. (通讯作者)
2. Zheng, S.; Tang, D.; Wang, X.; Liu, C.; Zuo, N.; Yan, R.; Wu, C.; Ma, J.; Wang, C.; Xu, H.; He, Y.; Liu, D.; Liu, S., Kif15 Is Required in the Development of Auditory System Using Zebrafish as a Model. Frontiers in molecular neuroscience 2022, 15, 844568. (通讯作者)
3. Xu, G.; Huang, Z.; Sheng, J.; Gao, X.; Wang, X.; Garcia, J. Q.; Wei, G.; Liu, D.; Gong, J., FGF binding protein 3 is required for spinal cord motor neuron development and regeneration in zebrafish. Exp Neurol 2022, 348, 113944. (通讯作者)
4. Wei, G.; Zhang, X.; Cai, C.; Sheng, J.; Xu, M.; Wang, C.; Gu, Q.; Guo, C.; Chen, F.; Liu, D.; Qian, F., Dual-Specificity Phosphatase 14 Regulates Zebrafish Hair Cell Formation Through Activation of p38 Signaling Pathway. Front Cell Neurosci 2022, 16, 840143. (通讯作者)
5. Sheng, J.; Xu, J.; Geng, K.; Liu, D., Sema6D Regulates Zebrafish Vascular Patterning and Motor Neuronal Axon Growth in Spinal Cord. Frontiers in molecular neuroscience 2022, 15, 854556. (通讯作者)
6. Sheng, J.; Gong, J.; Shi, Y.; Wang, X.; Liu, D., MicroRNA-22 coordinates vascular and motor neuronal pathfinding via sema4 during zebrafish development. Open Biol 2022, 12 (4), 210315. (通讯作者)
7. Qian, P.; Kang, J.; Liu, D.; Xie, G., Single Cell Transcriptome Sequencing of Zebrafish Testis Revealed Novel Spermatogenesis Marker Genes and Stronger Leydig-Germ Cell Paracrine Interactions. Front Genet 2022, 13, 851719. (通讯作者)
8. Qian, F.; Jiang, X.; Chai, R.; Liu, D., The Roles of Solute Carriers in Auditory Function. Front Genet 2022, 13, 823049. (通讯作者)
9. Lv, F.; Ge, X.; Qian, P.; Lu, X.; Liu, D.; Chen, C., Neuron navigator 3 (NAV3) is required for heart development in zebrafish. Fish physiology and biochemistry 2022. (通讯作者)
10. Hu, S. Q.; Xu, H. M.; Qian, F. P.; Chen, C. S.; Wang, X.; Liu, D.; Cheng, L., Interferon regulatory factor-7 is required for hair cell development during zebrafish embryogenesis. Dev Neurobiol 2022, 82 (1), 88-97. (通讯作者)
11. Chen, C.; Liu, D., Establishment of Zebrafish Models for Diabetes Mellitus and Its Microvascular Complications. J Vasc Res 2022, 1-9. (通讯作者)
12. Zhou, J.; Liang, W.; Wang, J.; Chen, J.; Liu, D.; Wang, X.; Wu, Y.; Zhang, Q.; Shen, D., An epileptic encephalopathy associated GABRG2 missense mutation leads to pre- and postsynaptic defects in zebrafish. Human molecular genetics 2021.
13. Zheng, Y.; Zhao, J.; Li, J.; Guo, Z.; Sheng, J.; Ye, X.; Jin, G.; Wang, C.; Chai, W.; Yan, J.; Liu, D.; Liang, X., SARS-CoV-2 spike protein causes blood coagulation and thrombosis by competitive binding to heparan sulfate. Int J Biol Macromol 2021, 193 (Pt B), 1124-1129. (通讯作者)
14. Zhang, K.; Liu, D.; Zhao, J.; Shi, S.; He, X.; Da, P.; You, Y.; You, B., Nuclear exosome HMGB3 secreted by nasopharyngeal carcinoma cells promotes tumour metastasis by inducing angiogenesis. Cell Death Dis 2021, 12 (6), 554. (共同一作)
15. Xie, G.; Zhang, X.; Lv, F.; Sang, M.; Hu, H.; Wang, J.; Liu, D., Nanopore Sequencing and Hi-C Based De Novo Assembly of Trachidermus fasciatus Genome. Genes (Basel) 2021, 12 (5). (通讯作者)
16. Shi, L.; Chen, C.; Yin, Z.; Wei, G.; Xie, G.; Liu, D., Systematic profiling of early regulators during tissue regeneration using zebrafish model. Wound Repair Regen 2021, 29 (1), 189-195. (通讯作者)
17. Pang, X. H.; Zheng, X. Y.; Lin, Y.; Zheng, H.; Xu, J.; Liu, D.; Jin, C. Y.; Zhang, L. P.; Zhang, Y. T.; Chu, J. S.; Chai, Y. C.; Yang, T., A Novel p.Tyr129His Variant in SIX1 Leads to Dominant, Delayed-onset Hearing Loss with Possible Association with Congenital Anosmia. Biomed Environ Sci 2021, 34 (4), 314-318.
18. Li, M.; Liu, J.; Liu, D.; Duan, X.; Zhang, Q.; Wang, D.; Zheng, Q.; Bai, X.; Lu, Z., Naringin attenuates cisplatin- and aminoglycoside-induced hair cell injury in the zebrafish lateral line via multiple pathways. J Cell Mol Med 2021, 25 (2), 975-989.
19. Hu, Z.; Zhang, C.; Wang, S.; Gao, S.; Wei, J.; Li, M.; Hou, L.; Mao, H.; Wei, Y.; Qi, T.; Liu, H.; Liu, D.; Lan, F.; Lu, D.; Wang, H.; Li, J.; Wang, Y., Discovery and engineering of small SlugCas9 with broad targeting range and high specificity and activity. Nucleic acids research 2021, 49 (7), 4008-4019.
20. Gong, J.; Qian, P.; Hu, Y.; Guo, C.; Wei, G.; Wang, C.; Cai, C.; Wang, H.; Liu, D., Claudin h Is Essential for Hair Cell Morphogenesis and Auditory Function in Zebrafish. Front Cell Dev Biol 2021, 9, 663995. (通讯作者)
21. Zhang, Z.; Hou, H.; Yu, S.; Zhou, C.; Zhang, X.; Li, N.; Zhang, S.; Song, K.; Lu, Y.; Liu, D.; Lu, H.; Xu, H., Inflammation-induced mammalian target of rapamycin signaling is essential for retina regeneration. Glia 2020, 68 (1), 111-127.
22. Zhang, Y.; Wang, Y.; Yao, X.; Wang, C.; Chen, F.; Liu, D.; Shao, M.; Xu, Z., Rbm24a Is Necessary for Hair Cell Development Through Regulating mRNA Stability in Zebrafish. Front Cell Dev Biol 2020, 8, 604026.
23. Wang, B.; Xu, M.; Li, M.; Wu, F.; Hu, S.; Chen, X.; Zhao, L.; Huang, Z.; Lan, F.; Liu, D.; Wang, Y., miR-25 Promotes Cardiomyocyte Proliferation by Targeting FBXW7. Mol Ther Nucleic Acids 2020, 19, 1299-1308.
24. Shen, D.; Chen, J.; Liu, D.; Shen, M.; Wang, X.; Wu, Y.; Ke, S.; Macdonald, R. L.; Zhang, Q., The GABRG2 F343L allele causes spontaneous seizures in a novel transgenic zebrafish model that can be treated with suberanilohydroxamic acid (SAHA). Ann Transl Med 2020, 8 (23), 1560.
25. Qian, F.; Wang, X.; Yin, Z.; Xie, G.; Yuan, H.; Liu, D.; Chai, R., The slc4a2b gene is required for hair cell development in zebrafish. Aging (Albany NY) 2020, 12 (19), 18804-18821. (通讯作者)
26. Liu, C.; Zhao, J.; Zhang, X.; Wei, G.; Hao, W.; Wang, X.; Yang, C.; Shi, Y.; Liu, D., Biomass-derived cellulose nanoparticles display considerable neurotoxicity in zebrafish. Int J Biol Macromol 2020, 165 (Pt B), 1783-1792. (通讯作者)
27. Hu, Z.; Wang, S.; Zhang, C.; Gao, N.; Li, M.; Wang, D.; Wang, D.; Liu, D.; Liu, H.; Ong, S. G.; Wang, H.; Wang, Y., A compact Cas9 ortholog from Staphylococcus Auricularis (SauriCas9) expands the DNA targeting scope. PLoS Biol 2020, 18 (3), e3000686.
28. Gong, J.; Hu, S.; Huang, Z.; Hu, Y.; Wang, X.; Zhao, J.; Qian, P.; Wang, C.; Sheng, J.; Lu, X.; Wei, G.; Liu, D., The Requirement of Sox2 for the Spinal Cord Motor Neuron Development of Zebrafish. Frontiers in molecular neuroscience 2020, 13, 34. (通讯作者)
29. Gao, C.; Guo, C.; Peng, Q.; Cao, J.; Shohat-Ophir, G.; Liu, D.; Pan, Y., Sex and Death: Identification of Feedback Neuromodulation Balancing Reproduction and Survival. Neuroscience bulletin 2020, 36 (12), 1429-1440.
30. Zhang, K.; Zhang, H.; Zhou, H.; Crookes, D.; Li, L.; Shao, Y.; Liu, D., Zebrafish Embryo Vessel Segmentation Using a Novel Dual ResUNet Model. Comput Intell Neurosci 2019, 2019, 8214975. (通讯作者)
31. Zhang, H.; Gao, Y.; Qian, P.; Dong, Z.; Hao, W.; Liu, D.; Duan, X., Expression analysis of Rab11 during zebrafish embryonic development. BMC Dev Biol 2019, 19 (1), 25.
32. Yu, B.; Yao, C.; Wang, Y.; Mao, S.; Wang, Y.; Wu, R.; Feng, W.; Chen, Y.; Yang, J.; Xue, C.; Liu, D.; Ding, F.; Gu, X., The Landscape of Gene Expression and Molecular Regulation Following Spinal Cord Hemisection in Rats. Frontiers in molecular neuroscience 2019, 12, 287.
33. Wang, Y. M.; Zheng, Y. F.; Yang, S. Y.; Yang, Z. M.; Zhang, L. N.; He, Y. Q.; Gong, X. H.; Liu, D.; Finnell, R. H.; Qiu, Z. L.; Du, Y. S.; Wang, H. Y., MicroRNA-197 controls ADAM10 expression to mediate MeCP2's role in the differentiation of neuronal progenitors. Cell Death Differ 2019, 26 (10), 1863-1879.
34. Wang, D.; Zhang, C.; Wang, B.; Li, B.; Wang, Q.; Liu, D.; Wang, H.; Zhou, Y.; Shi, L.; Lan, F.; Wang, Y., Optimized CRISPR guide RNA design for two high-fidelity Cas9 variants by deep learning. Nat Commun 2019, 10 (1), 4284.
35. Shi, Y.; Wang, X.; Shi, Y.; Zhang, J.; Zhao, S.; Yin, Z.; Xu, G.; Duan, X.; Guo, Z.; Liang, X.; Liu, D., Two Compounds Isolated From Ganglioside GM1 Promote Angiogenesis in Zebrafish. J Cardiovasc Pharmacol 2019, 74 (1), 71-79. (通讯作者)
36. Qin, Y.; Wang, S.; Duan, X.; Liu, D., Expression analysis of the aquaporins during zebrafish embryonic development. Gene expression patterns : GEP 2019, 32, 38-43. (通讯作者)
37. Li, L.; Zhu, M.; Wu, W.; Qin, B.; Gu, J.; Tu, Y.; Chen, J.; Liu, D.; Shi, Y.; Liu, X.; Sang, A.; Ding, D., Brivanib, a multitargeted small-molecule tyrosine kinase inhibitor, suppresses laser-induced CNV in a mouse model of neovascular AMD. J Cell Physiol 2019.
38. Dong, Z.; Wu, S.; Zhu, C.; Wang, X.; Li, Y.; Chen, X.; Liu, D.; Qiang, L.; Baas, P. W.; Liu, M., Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9-mediated kif15 mutations accelerate axonal outgrowth during neuronal development and regeneration in zebrafish. Traffic 2019, 20 (1), 71-81.
39. Yan, W.; Liu, W.; Qi, J.; Fang, Q.; Fan, Z.; Sun, G.; Han, Y.; Zhang, D.; Xu, L.; Wang, M.; Li, J.; Chen, F.; Liu, D.; Chai, R.; Wang, H., A Three-Dimensional Culture System with Matrigel Promotes Purified Spiral Ganglion Neuron Survival and Function In Vitro. Molecular neurobiology 2018, 55 (3), 2070-2084. (通讯作者)
40. Shan, Y.; You, B.; Shi, S.; Shi, W.; Zhang, Z.; Zhang, Q.; Gu, M.; Chen, J.; Bao, L.; Liu, D.; You, Y., Hypoxia-Induced Matrix Metalloproteinase-13 Expression in Exosomes from Nasopharyngeal Carcinoma Enhances Metastases. Cell Death Dis 2018, 9 (3), 382. (通讯作者)
41. Li, B.; Yu, L.; Liu, D.; Yang, X.; Zheng, Y.; Gui, Y.; Wang, H., MIB1 Mutations Reduce Notch Signaling Activation and Contribute to Congenital Heart Disease. Clin Sci (Lond) 2018.
42. Gong, J.; Chai, L.; Xu, G.; Ni, Y.; Liu, D., The expression of natriuretic peptide receptors in developing zebrafish embryos. Gene expression patterns : GEP 2018, 29, 65-71. (通讯作者)
43. Zhang, J.; Qi, J.; Wu, S.; Peng, L.; Shi, Y.; Yang, J.; Yin, Z.; Gao, Y.; Wang, C.; Gong, J.; Zhang, H.; Zhang, J.; Liu, D., Fatty Acid Binding Protein 11a Is Required for Brain Vessel Integrity in Zebrafish. Frontiers in physiology 2017, 8, 214. (通讯作者)
44. Xie, Y.; Wang, D.; Lan, F.; Wei, G.; Ni, T.; Chai, R.; Liu, D.; Hu, S.; Li, M.; Li, D.; Wang, H.; Wang, Y., An episomal vector-based CRISPR/Cas9 system for highly efficient gene knockout in human pluripotent stem cells. Scientific reports 2017, 7 (1), 2320.
45. Mu, Z.; Zhang, S.; He, C.; Hou, H.; Liu, D.; Hu, N.; Xu, H., Expression of SoxC Transcription Factors during Zebrafish Retinal and Optic Nerve Regeneration. Neuroscience bulletin 2017, 33 (1), 53-61.
46. Lv, F.; Zhu, C.; Yan, X.; Wang, X.; Liu, D., Generation of a mef2aa:EGFP transgenic zebrafish line that expresses EGFP in muscle cells. Fish physiology and biochemistry 2017, 43 (1), 287-294. (通讯作者)
47. Jin, D.; Zhu, D.; Fang, Y.; Chen, Y.; Yu, G.; Pan, W.; Liu, D.; Li, F.; Zhong, T. P., Vegfa signaling regulates diverse artery/vein formation in vertebrate vasculatures. Journal of genetics and genomics 2017, 44 (10), 483-492.
48. He, Z.; Guo, L.; Shu, Y.; Fang, Q.; Zhou, H.; Liu, Y.; Liu, D.; Lu, L.; Zhang, X.; Ding, X.; Liu, D.; Tang, M.; Kong, W.; Sha, S.; Li, H.; Gao, X.; Chai, R., Autophagy protects auditory hair cells against neomycin-induced damage. Autophagy 2017, 1-21.
49. He, Y.; Lu, X.; Qian, F.; Liu, D.; Chai, R.; Li, H., Insm1a Is Required for Zebrafish Posterior Lateral Line Development. Frontiers in molecular neuroscience 2017, 10, 241.
50. Gong, J.; Wang, X.; Zhu, C.; Dong, X.; Zhang, Q.; Wang, X.; Duan, X.; Qian, F.; Shi, Y.; Gao, Y.; Zhao, Q.; Chai, R.; Liu, D., Insm1a Regulates Motor Neuron Development in Zebrafish. Frontiers in molecular neuroscience 2017, 10, 274. (通讯作者)
51. Zhang, S.; Mu, Z.; He, C.; Zhou, M.; Liu, D.; Zhao, X. F.; Goldman, D.; Xu, H., Antiviral Drug Ganciclovir Is a Potent Inhibitor of the Proliferation of Muller Glia-Derived Progenitors During Zebrafish Retinal Regeneration. Investigative ophthalmology & visual science 2016, 57 (4), 1991-2000.
52. Wang, X.; Yuan, W.; Wang, X.; Qi, J.; Qin, Y.; Shi, Y.; Zhang, J.; Gong, J.; Dong, Z.; Liu, X.; Sun, C.; Chai, R.; Le Noble, F.; Liu, D., The somite-secreted factor Maeg promotes zebrafish embryonic angiogenesis. Oncotarget2016, 7 (47), 77749-77763. (通讯作者)
53. Shi, Y. W.; Yuan, W.; Wang, X.; Gong, J.; Zhu, S. X.; Chai, L. L.; Qi, J. L.; Qin, Y. Y.; Gao, Y.; Zhou, Y. L.; Fan, X. L.; Ji, C. Y.; Wu, J. Y.; Wang, Z. W.; Liu, D., Combretastatin A-4 efficiently inhibits angiogenesis and induces neuronal apoptosis in zebrafish. Scientific reports 2016, 6, 30189. (通讯作者)
54. He, Z.; Zhang, S.; Song, Q.; Li, W.; Liu, D.; Li, H.; Tang, M.; Chai, R., The structural development of primary cultured hippocampal neurons on a graphene substrate. Colloids and surfaces. B, Biointerfaces 2016, 146, 442-51.
55. Wang, X.; Wang, X.; Yuan, W.; Chai, R.; Liu, D., Egfl6 is involved in zebrafish notochord development. Fish physiology and biochemistry 2015, 41 (4), 961-9. (通讯作者)
56. Wang, X.; Chong, M.; Wang, X.; Wang, H.; Zhang, J.; Xu, H.; Zhang, J.; Liu, D., Block the function of nonmuscle myosin II by blebbistatin induces zebrafish embryo cardia bifida. In vitro cellular & developmental biology. Animal 2015, 51 (3), 211-7.
57. Xu, M.; Liu, D.; Dong, Z.; Wang, X.; Wang, X.; Liu, Y.; Baas, P. W.; Liu, M., Kinesin-12 influences axonal growth during zebrafish neural development. Cytoskeleton 2014, 71 (10), 555-63.
58. Wang, X.; Li, L.; Liu, D., Expression analysis of integrin beta1 isoforms during zebrafish embryonic development. Gene expression patterns : GEP 2014, 16 (2), 86-92. (通讯作者)
59. Sang, Q.; Zhang, J.; Feng, R.; Wang, X.; Li, Q.; Zhao, X.; Xing, Q.; Chen, W.; Du, J.; Sun, S.; Chai, R.; Liu, D.; Jin, L.; He, L.; Li, H.; Wang, L., Ildr1b is essential for semicircular canal development, migration of the posterior lateral line primordium and hearing ability in zebrafish: implications for a role in the recessive hearing impairment DFNB42. Human molecular genetics 2014, 23 (23), 6201-11.
60. Li, S.; Liu, Q.; Wang, Y.; Gu, Y.; Liu, D.; Wang, C.; Ding, G.; Chen, J.; Liu, J.; Gu, X., Differential gene expression profiling and biological process analysis in proximal nerve segments after sciatic nerve transection. PLoS One 2013, 8 (2), e57000.
61. Jiang, Q.; Lagos-Quintana, M.; Liu, D.; Shi, Y.; Helker, C.; Herzog, W.; le Noble, F., miR-30a regulates endothelial tip cell formation and arteriolar branching. Hypertension 2013, 62 (3), 592-8.
62. Huang, Y.; Wang, X.; Xu, M.; Liu, M.; Liu, D., Nonmuscle myosin II-B (myh10) expression analysis during zebrafish embryonic development. Gene expression patterns : GEP 2013, 13 (7), 265-70.
63. Liu, D.; Krueger, J.; Le Noble, F., The role of blood flow and microRNAs in blood vessel development. Int J Dev Biol 2011, 55 (4-5), 419-29.
64. Krueger, J.; Liu, D.; Scholz, K.; Zimmer, A.; Shi, Y.; Klein, C.; Siekmann, A.; Schulte-Merker, S.; Cudmore, M.; Ahmed, A.; le Noble, F., Flt1 acts as a negative regulator of tip cell formation and branching morphogenesis in the zebrafish embryo. Development 2011, 138 (10), 2111-20.
65. Klein, C.; Mikutta, J.; Krueger, J.; Scholz, K.; Brinkmann, J.; Liu, D.; Veerkamp, J.; Siegel, D.; Abdelilah-Seyfried, S.; le Noble, F., Neuron navigator 3a regulates liver organogenesis during zebrafish embryogenesis. Development 2011, 138 (10), 1935-45.
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中文论文：
1. 张晶晶，王新，刘东，C型利钠肽基因调控斑马鱼胚胎血管发育，生理学报，2017, 69(1): 11–16 (通讯作者)
2. 吕峰，石运伟，王新，刘东，严兴洪，microRNA-10a/b通过抑制Mib1调节斑马鱼神经元的发育，中国细胞生物学学报，2017, 39(2): 191–196 (通讯作者)
3. 王鸿奎，王学谦，王新，袁玮，刘东，非肌性肌球蛋白II-B调节斑马鱼咽弓的发育, 解剖学报，2016, 47(1):113-116 (通讯作者)
4. 袁玮，浦超，Rupesh Puri，石运伟，王新，李石营，刘东，Non-muscle Myosin II-A调节斑马鱼胚胎发育过程中肠内分泌细胞的极化，中国细胞生物学报，2015, 37(3): 328–334 (通讯作者)
5. 王新，张素珍，王学谦，李丽萍，张晶晶，刘东，流式细胞仪分选转基因斑马鱼胚胎荧光标记细胞的一种快速方法，中国细胞生物学报，2014, 36(3): 356–360 (通讯作者)
6. 刘雪静，王雪雯，石运伟，王新，高煜，刘东，生长激素促进斑马鱼尾鳍的再生，中国实验动物学报，2019, 27(2): 154–159 (通讯作者)
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